CODES+ISSS '06 Proceedings of the 4th international conference on Hardware/software codesign and system synthesis
Aquacore: a programmable architecture for microfluidics
Proceedings of the 34th annual international symposium on Computer architecture
Electronic Detection of DNA Hybridization: Toward CMOS Microarrays
IEEE Design & Test
Placement of defect-tolerant digital microfluidic biochips using the T-tree formulation
ACM Journal on Emerging Technologies in Computing Systems (JETC)
ACM Journal on Emerging Technologies in Computing Systems (JETC)
High-level synthesis of digital microfluidic biochips
ACM Journal on Emerging Technologies in Computing Systems (JETC)
BioRoute: a network-flow based routing algorithm for digital microfluidic biochips
Proceedings of the 2007 IEEE/ACM international conference on Computer-aided design
A high-performance droplet router for digital microfluidic biochips
Proceedings of the 2008 international symposium on Physical design
A progressive-ILP based routing algorithm for cross-referencing biochips
Proceedings of the 45th annual Design Automation Conference
ILP-based pin-count aware design methodology for microfluidic biochips
Proceedings of the 46th Annual Design Automation Conference
A progressive-ILP-based routing algorithm for the synthesis of cross-referencing biochips
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
A soft multi-core architecture for edge detection and data analysis of microarray images
Journal of Systems Architecture: the EUROMICRO Journal
On-line testing of lab-on-chip using reconfigurable digital-microfluidic compactors
International Journal of Parallel Programming
ICCD'09 Proceedings of the 2009 IEEE international conference on Computer design
Cross-contamination aware design methodology for pin-constrained digital microfluidic biochips
Proceedings of the 47th Design Automation Conference
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
ILP-based pin-count aware design methodology for microfluidic biochips
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
A contamination aware droplet routing algorithm for the synthesis of digital microfluidic biochips
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
Fault Diagnosis in Lab-on-Chip Using Digital Microfluidic Logic Gates
Journal of Electronic Testing: Theory and Applications
Test Strategies for Electrode Degradation in Bio-Fluidic Microsystems
Journal of Electronic Testing: Theory and Applications
Journal of Electronic Testing: Theory and Applications
Proceedings of the 48th Design Automation Conference
Digital microfluidic biochips: recent research and emerging challenges
CODES+ISSS '11 Proceedings of the seventh IEEE/ACM/IFIP international conference on Hardware/software codesign and system synthesis
Proceedings of the International Conference on Computer-Aided Design
A network-flow based pin-count aware routing algorithm for broadcast electrode-addressing EWOD chips
Proceedings of the International Conference on Computer-Aided Design
Digital microfluidic biochips: a vision for functional diversity and more than Moore
Proceedings of the International Conference on Computer-Aided Design
A SAT-based routing algorithm for cross-referencing biochips
Proceedings of the System Level Interconnect Prediction Workshop
Integrated fluidic-chip co-design methodology for digital microfluidic biochips
Proceedings of the 2012 ACM international symposium on International Symposium on Physical Design
Voltage-aware chip-level design for reliability-driven pin-constrained EWOD chips
Proceedings of the International Conference on Computer-Aided Design
Reliability-driven chip-level design for high-frequency digital microfluidic biochips
Proceedings of the 2014 on International symposium on physical design
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Microfluidics-based biochips are soon expected to revolutionize clinical diagnosis, deoxyribonucleic acid (DNA) sequencing, and other laboratory procedures involving molecular biology. In contrast to continuous-flow systems that rely on permanently etched microchannels, micropumps, and microvalves, digital microfluidics offers a scalable system architecture and dynamic reconfigurability; groups of unit cells in a microfluidics array can be reconfigured to change their functionality during the concurrent execution of a set of bioassays. As more bioassays are executed concurrently on a biochip, system integration and design complexity are expected to increase dramatically. This paper presents an overview of an integrated system-level design methodology that attempts to address key issues in the synthesis, testing and reconfiguration of digital microfluidics-based biochips. Different actuation mechanisms for microfluidics-based biochips, and associated design-automation trends and challenges are also discussed. The proposed top-down design-automation approach is expected to relieve biochip users from the burden of manual optimization of bioassays, time-consuming hardware design, and costly testing and maintenance procedures, and it will facilitate the integration of fluidic components with a microelectronic component in next-generation systems-on-chips (SOCs).