A class of min-cut placement algorithms
DAC '77 Proceedings of the 14th Design Automation Conference
Evaluation of Placement Techniques for DNA Probe Array Layout
Proceedings of the 2003 IEEE/ACM international conference on Computer-aided design
Unified high-level synthesis and module placement for defect-tolerant microfluidic biochips
Proceedings of the 42nd annual Design Automation Conference
Architectural-level synthesis of digital microfluidics-based biochips
Proceedings of the 2004 IEEE/ACM International conference on Computer-aided design
Design automation for microfluidics-based biochips
ACM Journal on Emerging Technologies in Computing Systems (JETC)
Droplet routing in the synthesis of digital microfluidic biochips
Proceedings of the conference on Design, automation and test in Europe: Proceedings
Module placement for fault-tolerant microfluidics-based biochips
Proceedings of the 41st annual Design Automation Conference
Placement of digital microfluidic biochips using the t-tree formulation
Proceedings of the 43rd annual Design Automation Conference
Defect-Aware Synthesis of Droplet-Based Microfluidic Biochips
VLSID '07 Proceedings of the 20th International Conference on VLSI Design held jointly with 6th International Conference: Embedded Systems
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
High parallelism, portability, and broad accessibility: Technologies for genomics
ACM Journal on Emerging Technologies in Computing Systems (JETC)
Automated design of digital microfluidic lab-on-chip under pin-count constraints
Proceedings of the 2008 international symposium on Physical design
Design and optimization of a digital microfluidic biochip for protein crystallization
Proceedings of the 2008 IEEE/ACM International Conference on Computer-Aided Design
A novel droplet routing algorithm for digital microfluidic biochips
Proceedings of the 20th symposium on Great lakes symposium on VLSI
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
Co-optimization of droplet routing and pin assignment in disposable digital microfluidic biochips
Proceedings of the 2011 international symposium on Physical design
Fault Diagnosis in Lab-on-Chip Using Digital Microfluidic Logic Gates
Journal of Electronic Testing: Theory and Applications
Integration, the VLSI Journal
Congestion-aware layout design for high-throughput digital microfluidic biochips
ACM Journal on Emerging Technologies in Computing Systems (JETC)
IEEE Transactions on Very Large Scale Integration (VLSI) Systems
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Microfluidics-based biochips, also referred to as lab-on-a-chip, are devices that integrate fluid-handling functions such as sample preparation, analysis, separation, and detection. This emerging technology combines electronics with biology to open new application areas such as point-of-care diagnosis, on-chip DNA analysis, and automated drug discovery. We propose a design automation method for pin-constrained biochips that manipulate nanoliter volumes of discrete droplets on a microfluidic array. In contrast to the direct-addressing scheme that has been studied thus far in the literature, we assign a small number of independent control pins to a large number of electrodes in the biochip, thereby reducing design complexity and product cost. The design procedure relies on a droplet-trace-based array partitioning scheme and an efficient pin assignment technique, referred to as the “Connect-5 algorithm.” The proposed method is evaluated using a set of multiplexed bioassays.