Chemical and Biological Applications of Digital-Microfluidic Devices
IEEE Design & Test
Integrated droplet routing in the synthesis of microfluidic biochips
Proceedings of the 44th annual Design Automation Conference
Placement of defect-tolerant digital microfluidic biochips using the T-tree formulation
ACM Journal on Emerging Technologies in Computing Systems (JETC)
ACM Journal on Emerging Technologies in Computing Systems (JETC)
Modeling and Controlling Parallel Tasks in Droplet-Based Microfluidic Systems
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
Performance Characterization of a Reconfigurable Planar-Array Digital Microfluidic System
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
On-line testing of lab-on-chip using reconfigurable digital-microfluidic compactors
International Journal of Parallel Programming
ACM Journal on Emerging Technologies in Computing Systems (JETC)
Design automation and test solutions for digital microfluidic biochips
IEEE Transactions on Circuits and Systems Part I: Regular Papers
Optimization of dilution and mixing of biochemical samples using digital microfluidic biochips
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
Fault Diagnosis in Lab-on-Chip Using Digital Microfluidic Logic Gates
Journal of Electronic Testing: Theory and Applications
Proceedings of the 48th Design Automation Conference
Digital microfluidic biochips: recent research and emerging challenges
CODES+ISSS '11 Proceedings of the seventh IEEE/ACM/IFIP international conference on Hardware/software codesign and system synthesis
Testing of Low-cost Digital Microfluidic Biochips with Non-Regular Array Layouts
Journal of Electronic Testing: Theory and Applications
Congestion-aware layout design for high-throughput digital microfluidic biochips
ACM Journal on Emerging Technologies in Computing Systems (JETC)
Dictionary-based error recovery in cyberphysical digital-microfluidic biochips
Proceedings of the International Conference on Computer-Aided Design
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Proteins crystallization is a commonly used technique for protein analysis and subsequent drug design. It predicts the three-dimensional arrangement of the constituent amino acids, which in turn indicates the specific biological function of a protein. Protein crystallization experiments are typically carried out manually on multi-well plates in the laboratory. These experiments are slow, expensive, and error-prone. We present the design of a multi-well plate microfluidic biochip for protein crystallization; this biochip can transfer protein samples, prepare candidate solutions, and carry out crystallization automatically. To reduce the manufacturing cost of such devices, we present an efficient algorithm to generate a pin-assignment plan for the proposed design. The resulting biochip enables control of a large number of on-chip electrodes using only a small number of pins. Based on the pin-constrained chip design, we present an efficient shuttle-passenger-like droplet manipulation method to achieve high-throughput and defect-tolerant well loading.