Parallel recombinative simulated annealing: a genetic algorithm
Parallel Computing
Unified high-level synthesis and module placement for defect-tolerant microfluidic biochips
Proceedings of the 42nd annual Design Automation Conference
Design automation for microfluidics-based biochips
ACM Journal on Emerging Technologies in Computing Systems (JETC)
Droplet routing in the synthesis of digital microfluidic biochips
Proceedings of the conference on Design, automation and test in Europe: Proceedings
Priority scheduling in digital microfluidics-based biochips
Proceedings of the conference on Design, automation and test in Europe: Proceedings
Chemical and Biological Applications of Digital-Microfluidic Devices
IEEE Design & Test
Placement of defect-tolerant digital microfluidic biochips using the T-tree formulation
ACM Journal on Emerging Technologies in Computing Systems (JETC)
High-level synthesis of digital microfluidic biochips
ACM Journal on Emerging Technologies in Computing Systems (JETC)
BioRoute: a network-flow based routing algorithm for digital microfluidic biochips
Proceedings of the 2007 IEEE/ACM international conference on Computer-aided design
Integrated droplet routing and defect tolerance in the synthesis of digital microfluidic biochips
ACM Journal on Emerging Technologies in Computing Systems (JETC)
Design and optimization of a digital microfluidic biochip for protein crystallization
Proceedings of the 2008 IEEE/ACM International Conference on Computer-Aided Design
Modeling and Controlling Parallel Tasks in Droplet-Based Microfluidic Systems
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
Performance Characterization of a Reconfigurable Planar-Array Digital Microfluidic System
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
A High-Performance Droplet Routing Algorithm for Digital Microfluidic Biochips
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
Digital microfluidic biochips: recent research and emerging challenges
CODES+ISSS '11 Proceedings of the seventh IEEE/ACM/IFIP international conference on Hardware/software codesign and system synthesis
Digital microfluidic biochips: a vision for functional diversity and more than Moore
Proceedings of the International Conference on Computer-Aided Design
Dictionary-based error recovery in cyberphysical digital-microfluidic biochips
Proceedings of the International Conference on Computer-Aided Design
A cyberphysical synthesis approach for error recovery in digital microfluidic biochips
DATE '12 Proceedings of the Conference on Design, Automation and Test in Europe
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Recent advances in digital microfluidics have led to tremendous interest in miniaturized lab-on-chip devices for biochemical analysis. Synthesis tools have also emerged for the automated design of lab-on-chip from the specifications of laboratory protocols. However, none of these tools consider control flow or address the problem of recovering from fluidic errors that can occur during on-chip bioassay execution. We present a synthesis method that incorporates control paths and an error-recovery mechanism in the design of a digital microfluidic lab-on-chip. Based on error-propagation estimates, we determine the best locations for fluidic checkpoints during biochip synthesis. A microcontroller coordinates the implementation of the control-flow-based bioassay by intercepting the synthesis results that are mapped to the software programs. Real-life bioassay applications are used as case studies to evaluate the proposed design method. For a representative protein assay, compared to a baseline chip design, the biochip with a control path can reduce the completion time by 30% when errors occur during the implementation of the bioassay.