VISI Physical Design Automation: Theory and Practice
VISI Physical Design Automation: Theory and Practice
Unified high-level synthesis and module placement for defect-tolerant microfluidic biochips
Proceedings of the 42nd annual Design Automation Conference
Architectural-level synthesis of digital microfluidics-based biochips
Proceedings of the 2004 IEEE/ACM International conference on Computer-aided design
Droplet routing in the synthesis of digital microfluidic biochips
Proceedings of the conference on Design, automation and test in Europe: Proceedings
Priority scheduling in digital microfluidics-based biochips
Proceedings of the conference on Design, automation and test in Europe: Proceedings
Module placement for fault-tolerant microfluidics-based biochips
Proceedings of the 41st annual Design Automation Conference
Automated design of pin-constrained digital microfluidic arrays for lab-on-a-chip applications*
Proceedings of the 43rd annual Design Automation Conference
Placement of digital microfluidic biochips using the t-tree formulation
Proceedings of the 43rd annual Design Automation Conference
Chemical and Biological Applications of Digital-Microfluidic Devices
IEEE Design & Test
Adaptive Cooling of Integrated Circuits Using Digital Microfluidics
Adaptive Cooling of Integrated Circuits Using Digital Microfluidics
Synthesis of Multiplexed Biofluidic Microchips
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
Modeling and Controlling Parallel Tasks in Droplet-Based Microfluidic Systems
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
Performance Characterization of a Reconfigurable Planar-Array Digital Microfluidic System
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
ACM Journal on Emerging Technologies in Computing Systems (JETC)
A contamination aware droplet routing algorithm for the synthesis of digital microfluidic biochips
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
Testing of Low-cost Digital Microfluidic Biochips with Non-Regular Array Layouts
Journal of Electronic Testing: Theory and Applications
Optimization algorithms for the design of digital microfluidic biochips: A survey
Computers and Electrical Engineering
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Microfluidic biochips are revolutionizing high-throughput DNA sequencing, immunoassays, and clinical diagnostics. As high-throughput bioassays are mapped to digital microfluidic platforms, the need for design automation techniques is being increasingly felt. Moreover, as most applications of biochips are safety-critical in nature, defect tolerance is an essential system attribute. Several synthesis tools have recently been proposed for the automated design of biochips from the specifications of laboratory protocols. However, only a few of these tools address the problem of defect tolerance. In addition, most of these methods do not consider the problem of droplet routing in microfluidic arrays. These methods typically rely on postsynthesis droplet routing to implement biochemical protocols. Such an approach is not only time consuming, but also imposes an undue burden on the chip user. Postsynthesis droplet routing does not guarantee that feasible droplet pathways can be found for area-constrained biochip layouts; nonroutable fabricated biochips must be discarded. We present a synthesis tool that integrates defect tolerance and droplet routing in the design flow. Droplet routability, defined as the ease with which droplet pathways can be determined, is estimated and integrated in the synthesis procedure. Presynthesis and postsynthesis defect-tolerance methods are also presented. We use a large-scale protein assay as a case study to evaluate the proposed synthesis method.