Finding minimum-cost circulations by canceling negative cycles
Journal of the ACM (JACM)
Network flows: theory, algorithms, and applications
Network flows: theory, algorithms, and applications
Dynamic Programming Treatment of the Travelling Salesman Problem
Journal of the ACM (JACM)
Design of Fault-Tolerant and Dynamically-Reconfigurable Microfluidic Biochips
Proceedings of the conference on Design, Automation and Test in Europe - Volume 2
Unified high-level synthesis and module placement for defect-tolerant microfluidic biochips
Proceedings of the 42nd annual Design Automation Conference
Architectural-level synthesis of digital microfluidics-based biochips
Proceedings of the 2004 IEEE/ACM International conference on Computer-aided design
Droplet routing in the synthesis of digital microfluidic biochips
Proceedings of the conference on Design, automation and test in Europe: Proceedings
Module placement for fault-tolerant microfluidics-based biochips
Proceedings of the 41st annual Design Automation Conference
Chemical and Biological Applications of Digital-Microfluidic Devices
IEEE Design & Test
Placement of defect-tolerant digital microfluidic biochips using the T-tree formulation
ACM Journal on Emerging Technologies in Computing Systems (JETC)
Integrated droplet routing and defect tolerance in the synthesis of digital microfluidic biochips
ACM Journal on Emerging Technologies in Computing Systems (JETC)
A progressive-ILP based routing algorithm for cross-referencing biochips
Proceedings of the 45th annual Design Automation Conference
SFCS '94 Proceedings of the 35th Annual Symposium on Foundations of Computer Science
Tabu search-based synthesis of dynamically reconfigurable digital microfluidic biochips
CASES '09 Proceedings of the 2009 international conference on Compilers, architecture, and synthesis for embedded systems
Proceedings of the 47th Design Automation Conference
Cross-contamination aware design methodology for pin-constrained digital microfluidic biochips
Proceedings of the 47th Design Automation Conference
Cross-contamination avoidance for droplet routing in digital microfluidic biochips
Proceedings of the Conference on Design, Automation and Test in Europe
Scheduling of microfluidic operations for reconfigurable two-dimensional electrowetting arrays
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
Modeling and Controlling Parallel Tasks in Droplet-Based Microfluidic Systems
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
Performance Characterization of a Reconfigurable Planar-Array Digital Microfluidic System
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
A High-Performance Droplet Routing Algorithm for Digital Microfluidic Biochips
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
BioRoute: A Network-Flow-Based Routing Algorithm for the Synthesis of Digital Microfluidic Biochips
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
Design of pin-constrained general-purpose digital microfluidic biochips
Proceedings of the 49th Annual Design Automation Conference
Optimization algorithms for the design of digital microfluidic biochips: A survey
Computers and Electrical Engineering
A cyberphysical synthesis approach for error recovery in digital microfluidic biochips
DATE '12 Proceedings of the Conference on Design, Automation and Test in Europe
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Recent advances of digital microfluidic biochips (DMFBs) have revolutionized the traditional laboratory procedures. By providing the droplet-based system, DMFB can perform real-time biological analysis and safety-critical biomedical applications. However, different droplets being transported and manipulated on the DMFB may introduce the contamination problem caused by liquid residue between different biomolecules. To overcome this problem, a wash droplet is introduced to clean the contaminations on the surface of the microfluidic array. However, current scheduling of wash droplet does not restrict the extra used cells and execution time of bioassay, thereby degrading the reliability and fault-tolerance significantly. In this paper, we propose a contamination aware droplet routing algorithm for DMFBs. To reduce the routing complexity and the used cells, we first construct preferred routing tracks by analyzing the global moving vector of droplets to guide the droplet routing. To cope with contaminations within one subproblem, we first apply a k- shortest path routing technique to minimize the contaminated spots. Then, to take advantage of multiple wash droplets, we adopt a minimum cost circulation (MCC) algorithm for optimal wash-droplet routing to simultaneously minimize used cells and the cleaning time. Since the droplet routing problem consists of several subproblems, a look-ahead prediction technique is further used to determine the contaminations between successive subproblems. After that, we can simultaneously clean both contaminations within one subproblem and those between successive subproblems by using the MCC-based algorithm to reduce the execution time and the used cells significantly. Based on four widely used bioassays, our algorithm reduces the used cells and the execution time significantly compared with the state-of-the-art algorithm.