Design of Fault-Tolerant and Dynamically-Reconfigurable Microfluidic Biochips
Proceedings of the conference on Design, Automation and Test in Europe - Volume 2
Module placement for fault-tolerant microfluidics-based biochips
Proceedings of the 41st annual Design Automation Conference
Placement of defect-tolerant digital microfluidic biochips using the T-tree formulation
ACM Journal on Emerging Technologies in Computing Systems (JETC)
High-level synthesis of digital microfluidic biochips
ACM Journal on Emerging Technologies in Computing Systems (JETC)
ILP-based pin-count aware design methodology for microfluidic biochips
Proceedings of the 46th Annual Design Automation Conference
An outlook on design technologies for future integrated systems
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
Droplet-routing-aware module placement for cross-referencing biochips
Proceedings of the 19th international symposium on Physical design
Cross-contamination aware design methodology for pin-constrained digital microfluidic biochips
Proceedings of the 47th Design Automation Conference
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
ILP-based pin-count aware design methodology for microfluidic biochips
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
A contamination aware droplet routing algorithm for the synthesis of digital microfluidic biochips
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
Optimization of dilution and mixing of biochemical samples using digital microfluidic biochips
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
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We present an architectural design and optimization methodology for performing biochemical reactions using two-dimensional (2-D) electrowetting arrays. We define a set of basic microfluidic operations and leverage electronic design automation principles for system partitioning, resource allocation, and operation scheduling. Fluidic operations are carried out through the electrostatic configuration of a set of grid points. While concurrency is desirable to minimize processing time, the size of the 2-D array limits the number of concurrent operations of any type. Furthermore, functional dependencies between the operations also limit concurrency. We use integer linear programming to minimize the processing time by automatically extracting parallelism from a biochemical assay. As a case study, we apply our optimization method to the polymerase chain reaction, which is an important step in many lab-on-a-chip biochemical applications