Droplet routing in the synthesis of digital microfluidic biochips
Proceedings of the conference on Design, automation and test in Europe: Proceedings
Chemical and Biological Applications of Digital-Microfluidic Devices
IEEE Design & Test
A progressive-ILP based routing algorithm for cross-referencing biochips
Proceedings of the 45th annual Design Automation Conference
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
Cross-contamination avoidance for droplet routing in digital microfluidic biochips
Proceedings of the Conference on Design, Automation and Test in Europe
Modeling and Controlling Parallel Tasks in Droplet-Based Microfluidic Systems
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
Performance Characterization of a Reconfigurable Planar-Array Digital Microfluidic System
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
A High-Performance Droplet Routing Algorithm for Digital Microfluidic Biochips
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
BioRoute: A Network-Flow-Based Routing Algorithm for the Synthesis of Digital Microfluidic Biochips
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
A contamination aware droplet routing algorithm for the synthesis of digital microfluidic biochips
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
On residue removal in digital microfluidic biochips
Proceedings of the 21st edition of the great lakes symposium on Great lakes symposium on VLSI
Digital microfluidic biochips: recent research and emerging challenges
CODES+ISSS '11 Proceedings of the seventh IEEE/ACM/IFIP international conference on Hardware/software codesign and system synthesis
Digital microfluidic biochips: a vision for functional diversity and more than Moore
Proceedings of the International Conference on Computer-Aided Design
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Digital microfluidic biochips are being utilized in many areas of biochemistry and biomedical sciences. Since cross-contamination between droplets of different biomolecules can lead to erroneous outcomes for bioassays, it is essential to avoid cross-contamination during droplet routing. We propose a wash-operation synchronization method to manipulate wash droplets to clean the residue that is left behind by sample and reagent droplets. We also synchronize wash-droplet routing with sample/reagent droplet-routing steps by controlling the arrival order of droplets at cross-contamination sites. The proposed method minimizes droplet-routing time without cross-contamination, and it is especially effective for tight chip-area constraints. A real-life application is used for evaluation.