Dictionary-based error recovery in cyberphysical digital-microfluidic biochips

  • Authors:
  • Yan Luo;Krishnendu Chakrabarty;Tsung-Yi Ho

  • Affiliations:
  • Duke University, Durham, NC;Duke University, Durham, NC;National Cheng Kung University, Tainan, Taiwan

  • Venue:
  • Proceedings of the International Conference on Computer-Aided Design
  • Year:
  • 2012

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Abstract

A cyberphysical digital microfluidics system is an emerging technology that enables the integration of fluid-handling operations, reaction-outcome detection, and automated error recovery on a biochip. The cyberphysical biochip system studied thus far suffers from the limitation of a significant increase in reaction time for error recovery. We present a hardware-assisted error-recovery method that relies on an error dictionary for rapid error recovery. The error-recovery procedure and dynamic resynthesis of a reaction, which is especially attractive for flash chemistry, can be implemented in real-time on a single-board microcontroller. In order to store the error dictionary in the limited memory available in the low-cost microcontroller, we describe two compaction techniques. We use three laboratorial protocols to demonstrate that, compared to software-based methods, the proposed dictionary-based error-recovery method has less impact on response time, and requires simple experimental setup, and only a small amount of memory.