On-line testing of lab-on-chip using reconfigurable digital-microfluidic compactors

Authors:
Yang Zhao;Krishnendu Chakrabarty
Affiliations:
Department of Electrical and Computer Engineering, Duke University, Durham, NC;Department of Electrical and Computer Engineering, Duke University, Durham, NC
Venue:
International Journal of Parallel Programming
Year:
2009

Citing 14
Cited 2

Built-in test for VLSI: pseudorandom techniques

Built-in test for VLSI: pseudorandom techniques
Testable Design and Testing of Micro-Electro-Fluidic Arrays

VTS '03 Proceedings of the 21st IEEE VLSI Test Symposium
Concurrent Testing of Droplet-Based Microfluidic Systems for Multiplexed Biomedical Assays

ITC '04 Proceedings of the International Test Conference on International Test Conference
Priority scheduling in digital microfluidics-based biochips

Proceedings of the conference on Design, automation and test in Europe: Proceedings
Test Planning and Test Resource Optimization for Droplet-Based Microfluidic Systems

Journal of Electronic Testing: Theory and Applications
Chemical and Biological Applications of Digital-Microfluidic Devices

IEEE Design & Test
Testing Microelectronic Biofluidic Systems

IEEE Design & Test
Testing and Diagnosis of Realistic Defects in Digital Microfluidic Biochips

Journal of Electronic Testing: Theory and Applications
Micro/nanofluidic computing

Communications of the ACM - ACM's plan to go online first
Placement of defect-tolerant digital microfluidic biochips using the T-tree formulation

ACM Journal on Emerging Technologies in Computing Systems (JETC)
Design and optimization of a digital microfluidic biochip for protein crystallization

Proceedings of the 2008 IEEE/ACM International Conference on Computer-Aided Design
Microfluidics-Based Biochips: Technology Issues, Implementation Platforms, and Design-Automation Challenges

IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
Modeling and Controlling Parallel Tasks in Droplet-Based Microfluidic Systems

IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
Performance Characterization of a Reconfigurable Planar-Array Digital Microfluidic System

IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems

Test Strategies for Electrode Degradation in Bio-Fluidic Microsystems

Journal of Electronic Testing: Theory and Applications
An Oscillation-Based Technique for Degradation Monitoring of Sensing and Actuation Electrodes Within Microfluidic Systems

Journal of Electronic Testing: Theory and Applications

Quantified Score

Hi-index	0.00

Visualization

Abstract

Dependability is an important system attribute for microfluidic lab-on-chip devices. On-line testing offers a promising method for detecting defects, fluidic abnormalities, and bioassay malfunctions during chip operation. However, previous techniques for reading test outcomes and analyzing pulse sequences are cumbersome, sensitive to the calibration of capacitive sensors, and error-prone. We present a built-in self-test (BIST) method for on-line testing of digital microfluidic lab-on-chip. This method utilizes microfluidic compactors based on droplet-based AND gates, which are implemented using digital microfluidics. An optimization method is proposed to schedule logic AND operations in the compactor to minimize the end time for the compaction procedure. Dynamic reconfiguration of these compactors ensures low area overhead and it allows BIST to be interleaved with bioassays in functional mode. We evaluate the on-line testing method using a multiplexed in vitro diagnostics bioassay.