Synthesis and Optimization of Digital Circuits
Synthesis and Optimization of Digital Circuits
Proceedings of the 41st annual Design Automation Conference
Design of Fault-Tolerant and Dynamically-Reconfigurable Microfluidic Biochips
Proceedings of the conference on Design, Automation and Test in Europe - Volume 2
Unified high-level synthesis and module placement for defect-tolerant microfluidic biochips
Proceedings of the 42nd annual Design Automation Conference
Defect Tolerance for Gracefully-Degradable Microfluidics-Based Biochips
VTS '05 Proceedings of the 23rd IEEE Symposium on VLSI Test
Architectural-level synthesis of digital microfluidics-based biochips
Proceedings of the 2004 IEEE/ACM International conference on Computer-aided design
Droplet routing in the synthesis of digital microfluidic biochips
Proceedings of the conference on Design, automation and test in Europe: Proceedings
Test Planning and Test Resource Optimization for Droplet-Based Microfluidic Systems
Journal of Electronic Testing: Theory and Applications
Module placement for fault-tolerant microfluidics-based biochips
Proceedings of the 41st annual Design Automation Conference
CODES+ISSS '06 Proceedings of the 4th international conference on Hardware/software codesign and system synthesis
Chemical and Biological Applications of Digital-Microfluidic Devices
IEEE Design & Test
Testing Microelectronic Biofluidic Systems
IEEE Design & Test
Testing and Diagnosis of Realistic Defects in Digital Microfluidic Biochips
Journal of Electronic Testing: Theory and Applications
Proceedings of the conference on Design, automation and test in Europe
Integrated droplet routing in the synthesis of microfluidic biochips
Proceedings of the 44th annual Design Automation Conference
Placement of defect-tolerant digital microfluidic biochips using the T-tree formulation
ACM Journal on Emerging Technologies in Computing Systems (JETC)
High-level synthesis of digital microfluidic biochips
ACM Journal on Emerging Technologies in Computing Systems (JETC)
BioRoute: a network-flow based routing algorithm for digital microfluidic biochips
Proceedings of the 2007 IEEE/ACM international conference on Computer-aided design
A high-performance droplet router for digital microfluidic biochips
Proceedings of the 2008 international symposium on Physical design
Broadcast electrode-addressing for pin-constrained multi-functional digital microfluidic biochips
Proceedings of the 45th annual Design Automation Conference
A progressive-ILP based routing algorithm for cross-referencing biochips
Proceedings of the 45th annual Design Automation Conference
Design and optimization of a digital microfluidic biochip for protein crystallization
Proceedings of the 2008 IEEE/ACM International Conference on Computer-Aided Design
Design-for-Testability for Digital Microfluidic Biochips
VTS '09 Proceedings of the 2009 27th IEEE VLSI Test Symposium
Cross-contamination avoidance for droplet routing in digital microfluidic biochips
Proceedings of the Conference on Design, Automation and Test in Europe
Composable Behavioral Models and Schematic-Based Simulation of Electrokinetic Lab-on-a-Chip Systems
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
System-Level Simulation of Flow-Induced Dispersion in Lab-on-a-Chip Systems
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
Journal of Electronic Testing: Theory and Applications
Proceedings of the 48th Design Automation Conference
Digital microfluidic biochips: recent research and emerging challenges
CODES+ISSS '11 Proceedings of the seventh IEEE/ACM/IFIP international conference on Hardware/software codesign and system synthesis
Path scheduling on digital microfluidic biochips
Proceedings of the 49th Annual Design Automation Conference
Module-Based Synthesis of Digital Microfluidic Biochips with Droplet-Aware Operation Execution
ACM Journal on Emerging Technologies in Computing Systems (JETC)
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Microfluidics-based biochips are revolutionizing high-throughput sequencing, parallel immunoassays, blood chemistry for clinical diagnostics, and drug discovery. These devices enable the precise control of nanoliter volumes of biochemical samples and reagents. They combine electronics with biology, and they integrate various bioassay operations, such as sample preparation, analysis, separation, and detection. Compared to conventional laboratory procedures, which are cumbersome and expensive, miniaturized biochips offer the advantages of higher sensitivity, lower cost due to smaller sample and reagent volumes, system integration, and less likelihood of human error. This tutorial paper provides an overview of droplet-based "digital" microfluidic biochips. It describes emerging computer-aided design (CAD) tools for the automated synthesis and optimization of biochips from bioassay protocols. Recent advances in fluidic-operation scheduling, module placement, droplet routing, pin-constrained chip design, and testing are presented. These CAD techniques allow biochip users to concentrate on the development of nanoscale bioassays, leaving chip optimization and implementation details to design-automation tools.