Chemical and Biological Applications of Digital-Microfluidic Devices
IEEE Design & Test
ACM Journal on Emerging Technologies in Computing Systems (JETC)
Automated design of digital microfluidic lab-on-chip under pin-count constraints
Proceedings of the 2008 international symposium on Physical design
Broadcast electrode-addressing for pin-constrained multi-functional digital microfluidic biochips
Proceedings of the 45th annual Design Automation Conference
Design and optimization of a digital microfluidic biochip for protein crystallization
Proceedings of the 2008 IEEE/ACM International Conference on Computer-Aided Design
ILP-based pin-count aware design methodology for microfluidic biochips
Proceedings of the 46th Annual Design Automation Conference
A two-stage ILP-based droplet routing algorithm for pin-constrained digital microfluidic biochips
Proceedings of the 19th international symposium on Physical design
CrossRouter: a droplet router for cross-referencing digital microfluidic biochips
Proceedings of the 2010 Asia and South Pacific Design Automation Conference
Pin-Constrained Designs of Digital Microfluidic Biochips for High-Throughput Bioassays
ISED '10 Proceedings of the 2010 International Symposium on Electronic System Design
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
A field-programmable pin-constrained digital microfluidic biochip
Proceedings of the 50th Annual Design Automation Conference
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Potential applications of digital microfluidic (DMF) biochips now include several areas of real-life applications like environmental monitoring, water and air pollutant detection, and food processing to name a few. In order to achieve sufficiently high throughput for these applications, several instances of the same bioassay may be required to be executed concurrently on different samples. As a straightforward implementation, several identical biochips can be integrated on a single substrate as a multichip to execute the assay for various samples concurrently. Controlling individual electrodes of such a chip by independent pins may not be acceptable since it increases the cost of fabrication. Thus, in order to keep the overall pin-count within an acceptable bound, all the respective electrodes of these individual pieces are connected internally underneath the chip so that they can be controlled with a single external control pin. In this article, we present an orientation strategy for layout of a multichip that reduces routing congestion and consequently facilitates wire routing for the electrode array. The electrode structure of the individual pieces of the multichip may be either direct-addressable or pin-constrained. The method also supports a hierarchical approach to wire routing that ensures scalability. In this scheme, the size of the biochip in terms of the total number of electrodes may be increased by a factor of four by increasing the number of routing layers by only one. In general, for a multichip with 4n identical blocks, (n + 1) layers are sufficient for wire routing.