Unified high-level synthesis and module placement for defect-tolerant microfluidic biochips
Proceedings of the 42nd annual Design Automation Conference
Droplet routing in the synthesis of digital microfluidic biochips
Proceedings of the conference on Design, automation and test in Europe: Proceedings
Chemical and Biological Applications of Digital-Microfluidic Devices
IEEE Design & Test
Integrated droplet routing in the synthesis of microfluidic biochips
Proceedings of the 44th annual Design Automation Conference
Placement of defect-tolerant digital microfluidic biochips using the T-tree formulation
ACM Journal on Emerging Technologies in Computing Systems (JETC)
ACM Journal on Emerging Technologies in Computing Systems (JETC)
BioRoute: a network-flow based routing algorithm for digital microfluidic biochips
Proceedings of the 2007 IEEE/ACM international conference on Computer-aided design
Broadcast electrode-addressing for pin-constrained multi-functional digital microfluidic biochips
Proceedings of the 45th annual Design Automation Conference
A two-stage ILP-based droplet routing algorithm for pin-constrained digital microfluidic biochips
Proceedings of the 19th international symposium on Physical design
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
CrossRouter: a droplet router for cross-referencing digital microfluidic biochips
Proceedings of the 2010 Asia and South Pacific Design Automation Conference
Modeling and Controlling Parallel Tasks in Droplet-Based Microfluidic Systems
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
A High-Performance Droplet Routing Algorithm for Digital Microfluidic Biochips
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
Digital microfluidic biochips: recent research and emerging challenges
CODES+ISSS '11 Proceedings of the seventh IEEE/ACM/IFIP international conference on Hardware/software codesign and system synthesis
Optimization algorithms for the design of digital microfluidic biochips: A survey
Computers and Electrical Engineering
Reliability-driven chip-level design for high-frequency digital microfluidic biochips
Proceedings of the 2014 on International symposium on physical design
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The number of independent input pins used to control the electrodes in digital microfluidic "biochips" is an important cost-driver in the emerging market place, especially for disposable PCB devices that are being developed for clinical and point-of-care diagnostics. However, most prior work on pin-constrained biochip design considers droplet routing and the assignment of pins to electrodes as independent problems. We propose aninteger linear programming (ILP)-based optimization method to solve the droplet-routing and the pin-mapping design problems concurrently. The proposed co-optimization method optimizes routing pathways, generates a single pin-assignment, and attempts to minimize the number of control pins. It also overcomes a major limitation of recent work on this problem---the method described in prior work can lead to infeasible designs due to the need to change the mapping of pins to electrodes dynamically during bioassay execution. The effectiveness of the proposed co-optimization method is demonstrated for a commercial biochip that is used to perform n-plex immunoassays, as well as an experimental chip for multiplexed in-vitro diagnostics.