Graph theory and its applications
Graph theory and its applications
Unified high-level synthesis and module placement for defect-tolerant microfluidic biochips
Proceedings of the 42nd annual Design Automation Conference
Droplet routing in the synthesis of digital microfluidic biochips
Proceedings of the conference on Design, automation and test in Europe: Proceedings
Priority scheduling in digital microfluidics-based biochips
Proceedings of the conference on Design, automation and test in Europe: Proceedings
Chemical and Biological Applications of Digital-Microfluidic Devices
IEEE Design & Test
Computer-Aided Design and Test for Digital Microfluidics
IEEE Design & Test
Placement of defect-tolerant digital microfluidic biochips using the T-tree formulation
ACM Journal on Emerging Technologies in Computing Systems (JETC)
ACM Journal on Emerging Technologies in Computing Systems (JETC)
High-level synthesis of digital microfluidic biochips
ACM Journal on Emerging Technologies in Computing Systems (JETC)
BioRoute: a network-flow based routing algorithm for digital microfluidic biochips
Proceedings of the 2007 IEEE/ACM international conference on Computer-aided design
A high-performance droplet router for digital microfluidic biochips
Proceedings of the 2008 international symposium on Physical design
Broadcast electrode-addressing for pin-constrained multi-functional digital microfluidic biochips
Proceedings of the 45th annual Design Automation Conference
Tabu search-based synthesis of dynamically reconfigurable digital microfluidic biochips
CASES '09 Proceedings of the 2009 international conference on Compilers, architecture, and synthesis for embedded systems
ILP-based pin-count aware design methodology for microfluidic biochips
Proceedings of the 46th Annual Design Automation Conference
VLSID '10 Proceedings of the 2010 23rd International Conference on VLSI Design
A two-stage ILP-based droplet routing algorithm for pin-constrained digital microfluidic biochips
Proceedings of the 19th international symposium on Physical design
Cross-contamination aware design methodology for pin-constrained digital microfluidic biochips
Proceedings of the 47th Design Automation Conference
CrossRouter: a droplet router for cross-referencing digital microfluidic biochips
Proceedings of the 2010 Asia and South Pacific Design Automation Conference
Optimization of dilution and mixing of biochemical samples using digital microfluidic biochips
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
Modeling and Controlling Parallel Tasks in Droplet-Based Microfluidic Systems
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
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The implementation of bioassays in pin-constrained digital microfluidic biochips may involve pin-actuation conflicts if the concurrently-implemented fluidic operations are not carefully synchronized. We propose a two-phase optimization method to identify and synchronize the fluidic operations that can be executed in parallel. The goal is to implement these fluidic operations without pin-actuation conflict, and minimize the duration of implementing the outcome sequence after synchronization. We also extend the synchronization method with the addition of a small number of control pins, in order to further minimize the completion time while avoiding pin-actuation conflicts. The effectiveness of the proposed synchronization method is demonstrated for a representative 3-plex assay performed on a commercial pin-constrained biochip and for multiplexed in-vitro diagnostics performed on an experimental pin-constrained biochip.