Electronic Detection of DNA Hybridization: Toward CMOS Microarrays

Authors:
Luca Benini;Carlotta Guiducci;Christian Paulus
Affiliations:
University of Bologna;ESPCI-Paris;Siemens AG
Venue:
IEEE Design & Test
Year:
2007

Citing 3
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Abstract

DNA microarrays are among the key technology enablers for the tumultuous development of biology and medicine triggered by high-throughput genomics. As microarray-based methods for analysis and diagnosis become more pervasive, there is an ever-growing demand for low-cost, highly integrated microarrays for point-of-care usage. This article focuses on fully electronic approaches that integrate DNA sensor arrays and circuits for transduction, amplification, digital conversion, and readout of signals on a single CMOS chip. Prototypes of these devices have obtained promising results.