Electronic Detection of DNA Hybridization: Toward CMOS Microarrays
IEEE Design & Test
Testing Microelectronic Biofluidic Systems
IEEE Design & Test
Fault co-simulation for test evaluation of heterogeneous integrated biological systems
Microelectronics Journal
Integration, the VLSI Journal
Proceedings of the eighth IEEE/ACM/IFIP international conference on Hardware/software codesign and system synthesis
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Microfluidics-based biochips offer a promising platform for massively parallel DNA analysis, automated drug discovery, and real-time biomolecular recognition. The first part of this paper introduces readers to digital microfluidics technology. The second part describes a recent technique for the automated design and synthesis of biochips. A clinical diagnostic procedure, namely multiplexed in-vitro diagnostics on human physiological fluids, is used to illustrate the design approach. The third part of the embedded tutorial is focused on test issues. It is important to ensure high reliability and availability of biochips as they are increasingly deployed for safety-critical applications. The tutorial includes a discussion of fault models, catastrophic fault testing, and concurrent test issues.