Computers and Intractability: A Guide to the Theory of NP-Completeness
Computers and Intractability: A Guide to the Theory of NP-Completeness
Architectural-level synthesis of digital microfluidics-based biochips
Proceedings of the 2004 IEEE/ACM International conference on Computer-aided design
Droplet routing in the synthesis of digital microfluidic biochips
Proceedings of the conference on Design, automation and test in Europe: Proceedings
Module placement for fault-tolerant microfluidics-based biochips
Proceedings of the 41st annual Design Automation Conference
CODES+ISSS '06 Proceedings of the 4th international conference on Hardware/software codesign and system synthesis
Placement of defect-tolerant digital microfluidic biochips using the T-tree formulation
ACM Journal on Emerging Technologies in Computing Systems (JETC)
Broadcast electrode-addressing for pin-constrained multi-functional digital microfluidic biochips
Proceedings of the 45th annual Design Automation Conference
ILP-based pin-count aware design methodology for microfluidic biochips
Proceedings of the 46th Annual Design Automation Conference
VLSID '10 Proceedings of the 2010 23rd International Conference on VLSI Design
ICCD'09 Proceedings of the 2009 IEEE international conference on Computer design
A network-flow based pin-count aware routing algorithm for broadcast electrode-addressing EWOD chips
Proceedings of the International Conference on Computer-Aided Design
Digital microfluidic biochips: a vision for functional diversity and more than Moore
Proceedings of the International Conference on Computer-Aided Design
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
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Recently, digital microfluidic biochips (DMFBs) have revolutionized many biochemical laboratory procedures and received much attention due to many advantages such as high throughput, automatic control, and low cost. To meet the challenges of increasing design complexity, computer-aided-design (CAD) tools have been involved to build DMFBs efficiently. Current CAD tools generally conduct a two-stage based design flow of fluidic-level synthesis followed by chip-level design to optimize fluidic behaviors and chip architecture separately. Nevertheless, existing fluidic-chip design gap will become even wider with a rapid escalation in the number of assay operations incorporated into a single DMFB. As more and more large-scale assay protocols are delivered in current emerging marketplace, this problem may potentially restrict the effectiveness and feasibility of the entire DMFB realization and thus needs to be solved quickly. In this paper, we propose the first fluidic-chip co-design methodology for DMFBs to effectively bridge the fluidic-chip design gap. Our work provides a comprehensive integration throughout fluidic-operation scheduling, chip layout generation, control pin assignment, and wiring solution to achieve higher design performance and feasibility. Experimental results show the effectiveness, robustness, and scalability of our co-design methodology on a set of real-life assay applications.