Constructing Level-2 Phylogenetic Networks from Triplets

  • Authors:
  • Leo van Iersel;Judith Keijsper;Steven Kelk;Leen Stougie;Ferry Hagen;Teun Boekhout

  • Affiliations:
  • University of Canterbury, Christchurch;Technische Universiteit Eindhoven, Eindhoven;Centrum voor Wiskunde en Informatica (CWI), Amsterdam;Centrum voor Wiskunde en Informatica (CWI) and Free University, Amsterdam;Centraalbureau voor Schimmelcultures (CBS), Utrecht;Centraalbureau voor Schimmelcultures (CBS), Utrecht

  • Venue:
  • IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB)
  • Year:
  • 2009

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Abstract

Jansson and Sung showed that, given a dense set of input triplets T (representing hypotheses about the local evolutionary relationships of triplets of taxa), it is possible to determine in polynomial time whether there exists a level-1 network consistent with T, and if so, to construct such a network [24]. Here, we extend this work by showing that this problem is even polynomial time solvable for the construction of level-2 networks. This shows that, assuming density, it is tractable to construct plausible evolutionary histories from input triplets even when such histories are heavily nontree-like. This further strengthens the case for the use of triplet-based methods in the construction of phylogenetic networks. We also implemented the algorithm and applied it to yeast data.