Introduction to algorithms
A translation approach to portable ontology specifications
Knowledge Acquisition - Special issue: Current issues in knowledge modeling
Interface of Inference Models with Concept and Medical Record Models
AIME '01 Proceedings of the 8th Conference on AI in Medicine in Europe: Artificial Intelligence Medicine
The description logic handbook: theory, implementation, and applications
The description logic handbook: theory, implementation, and applications
A reference ontology for biomedical informatics: the foundational model of anatomy
Journal of Biomedical Informatics - Special issue: Unified medical language system
The foundational model of anatomy in OWL: Experience and perspectives
Web Semantics: Science, Services and Agents on the World Wide Web
Medical Domain Ontology Construction Approach: A Basis for Medical Decision Support
CBMS '07 Proceedings of the Twentieth IEEE International Symposium on Computer-Based Medical Systems
Clinical practice guidelines: A case study of combining OWL-S, OWL, and SWRL
Knowledge-Based Systems
Combining OpenEHR Archetype Definitions with SWRL Rules --- A Translation Approach
WSKS '08 Proceedings of the 1st world summit on The Knowledge Society: Emerging Technologies and Information Systems for the Knowledge Society
A model-driven approach for representing clinical archetypes for Semantic Web environments
Journal of Biomedical Informatics
Binding ontologies and coding systems to electronic health records and messages
Applied Ontology - Biomedical Ontology in Action
OWL rules: A proposal and prototype implementation
Web Semantics: Science, Services and Agents on the World Wide Web
Extending SWRL to enhance mathematical support
RR'07 Proceedings of the 1st international conference on Web reasoning and rule systems
Developing guideline-based decision support systems using protégé and jess
Computer Methods and Programs in Biomedicine
Supporting rule system interoperability on the semantic web with SWRL
ISWC'05 Proceedings of the 4th international conference on The Semantic Web
OWL-Eu: adding customised datatypes into OWL
ESWC'05 Proceedings of the Second European conference on The Semantic Web: research and Applications
Associating Clinical Archetypes Through UMLS Metathesaurus Term Clusters
Journal of Medical Systems
Proceedings of the 2nd ACM SIGHIT International Health Informatics Symposium
Semantic integration of patient data and quality indicators based on openEHR archetypes
BPM' 2012 Proceedings of the 2012 international conference on Process Support and Knowledge Representation in Health Care
OWL-based reasoning methods for validating archetypes
Journal of Biomedical Informatics
SAMS --- A Systems Architecture for Developing Intelligent Health Information Systems
Journal of Medical Systems
STEP: An ontology-based smart clinical document template editing and production system
Expert Systems with Applications: An International Journal
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Semantic interoperability is essential to facilitate the computerized support for alerts, workflow management and evidence-based healthcare across heterogeneous electronic health record (EHR) systems. Clinical archetypes, which are formal definitions of specific clinical concepts defined as specializations of a generic reference (information) model, provide a mechanism to express data structures in a shared and interoperable way. However, currently available archetype languages do not provide direct support for mapping to formal ontologies and then exploiting reasoning on clinical knowledge, which are key ingredients of full semantic interoperability, as stated in the SemanticHEALTH report [1]. This paper reports on an approach to translate definitions expressed in the openEHR Archetype Definition Language (ADL) to a formal representation expressed using the Ontology Web Language (OWL). The formal representations are then integrated with rules expressed with Semantic Web Rule Language (SWRL) expressions, providing an approach to apply the SWRL rules to concrete instances of clinical data. Sharing the knowledge expressed in the form of rules is consistent with the philosophy of open sharing, encouraged by archetypes. Our approach also allows the reuse of formal knowledge, expressed through ontologies, and extends reuse to propositions of declarative knowledge, such as those encoded in clinical guidelines. This paper describes the ADL-to-OWL translation approach, describes the techniques to map archetypes to formal ontologies, and demonstrates how rules can be applied to the resulting representation. We provide examples taken from a patient safety alerting system to illustrate our approach.