Active shape models—their training and application
Computer Vision and Image Understanding
Deformable M-Reps for 3D Medical Image Segmentation
International Journal of Computer Vision - Special Issue on Research at the University of North Carolina Medical Image Display Analysis Group (MIDAG)
Statistical variability in nonlinear spaces: application to shape analysis and dt-mri
Statistical variability in nonlinear spaces: application to shape analysis and dt-mri
Hypothesis testing with nonlinear shape models
IPMI'05 Proceedings of the 19th international conference on Information Processing in Medical Imaging
ISBI'09 Proceedings of the Sixth IEEE international conference on Symposium on Biomedical Imaging: From Nano to Macro
Population-based fitting of medial shape models with correspondence optimization
IPMI'07 Proceedings of the 20th international conference on Information processing in medical imaging
Simultaneous brain structures segmentation combining shape and pose forces
MBIA'11 Proceedings of the First international conference on Multimodal brain image analysis
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A main focus of statistical shape analysis is the description of variability of a population of geometric objects. In this paper, we present work in progress towards modeling the shape and pose variability of sets of multiple objects. Principal geodesic analysis (PGA) is the extension of the standard technique of principal component analysis (PCA) into the nonlinear Riemannian symmetric space of pose and our medial m-rep shape description, a space in which use of PCA would be incorrect. In this paper, we discuss the decoupling of pose and shape in multi-object sets using different normalization settings. Further, we introduce new methods of describing the statistics of object pose using a novel extension of PGA, which previously has been used for global shape statistics. These new pose statistics are then combined with shape statistics to form a more complete description of multi-object complexes. We demonstrate our methods in an application to a longitudinal pediatric autism study with object sets of 10 subcortical structures in a population of 20 subjects. The results show that global scale accounts for most of the major mode of variation across time. Furthermore, the PGA components and the corresponding distribution of different subject groups vary significantly depending on the choice of normalization, which illustrates the importance of global and local pose alignment in multi-object shape analysis.