Shifting patterns discovery in microarrays with evolutionary algorithms

  • Authors:
  • Beatriz Pontes;Raúl Giráldez;Jesús S. Aguilar–Ruiz

  • Affiliations:
  • Department of Computer Science, University of Seville, Sevilla, Spain;Area of Computer Science, University of Pablo de Olavide, Sevilla, Spain;Area of Computer Science, University of Pablo de Olavide, Sevilla, Spain

  • Venue:
  • KES'06 Proceedings of the 10th international conference on Knowledge-Based Intelligent Information and Engineering Systems - Volume Part II
  • Year:
  • 2006

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Abstract

In recent years, the interest in extracting useful knowledge from gene expression data has experimented an enormous increase with the development of microarray technique. Biclustering is a recent technique that aims at extracting a subset of genes that show a similar behaviour for a subset conditions. It is important, therefore, to measure the quality of a bicluster, and a way to do that would be checking if each data submatrix follows a specific trend, represented by a pattern. In this work, we present an evolutionary algorithm for finding significant shifting patterns which depict the general behaviour within each bicluster. The empirical results we have obtained confirm the quality of our proposal, obtaining very accurate solutions for the biclusters used.