Feature subset selection by genetic algorithms and estimation of distribution algorithms

  • Authors:
  • I. Inza;M. Merino;P. Larrañaga;J. Quiroga;B. Sierra;M. Girala

  • Affiliations:
  • Department of Computer Science and Artificial Intelligence, P.O. Box 649, University of the Basque Country, E-20080 Donostia-San Sebastián, Spain;Basque Health Service-Osakidetza, Comarca Gipuzkoa-Este, Avenida Navarra 14, E-20013 Donostia-San Sebastián, Spain;Department of Computer Science and Artificial Intelligence, P.O. Box 649, University of the Basque Country, E-20080 Donostia-San Sebastián, Spain;Facultad de Medicina, University Clinic of Navarra, E-31080 Pamplona-Iruña, Spain;Department of Computer Science and Artificial Intelligence, P.O. Box 649, University of the Basque Country, E-20080 Donostia-San Sebastián, Spain;Facultad de Medicina, University Clinic of Navarra, E-31080 Pamplona-Iruña, Spain

  • Venue:
  • Artificial Intelligence in Medicine
  • Year:
  • 2001

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Abstract

The transjugular intrahepatic portosystemic shunt (TIPS) is an interventional treatment for cirrhotic patients with portal hypertension. In the light of our medical staff's experience, the consequences of TIPS are not homogeneous for all the patients and a subgroup dies in the first 6 months after TIPS placement. Actually, there is no risk indicator to identify this subgroup of patients before treatment. An investigation for predicting the survival of cirrhotic patients treated with TIPS is carried out using a clinical database with 107 cases and 77 attributes. Four supervised machine learning classifiers are applied to discriminate between both subgroups of patients. The application of several feature subset selection (FSS) techniques has significantly improved the predictive accuracy of these classifiers and considerably reduced the amount of attributes in the classification models. Among FSS techniques, FSS-TREE, a new randomized algorithm inspired on the new EDA (estimation of distribution algorithm) paradigm has obtained the best average accuracy results for each classifier.