The society of mind
Constraint propagation with interval labels
Artificial Intelligence
Probabilistic reasoning in intelligent systems: networks of plausible inference
Probabilistic reasoning in intelligent systems: networks of plausible inference
A computational scheme for reasoning in dynamic probabilistic networks
UAI '92 Proceedings of the eighth conference on Uncertainty in Artificial Intelligence
A neural network theory of proportional analogy-making
Neural Networks
Introduction to Bayesian Networks
Introduction to Bayesian Networks
Learning Dynamic Bayesian Networks
Adaptive Processing of Sequences and Data Structures, International Summer School on Neural Networks, "E.R. Caianiello"-Tutorial Lectures
An Introduction to the Kalman Filter
An Introduction to the Kalman Filter
A Model of Prefrontal Cortex Dopaminergic Modulation during the Delayed Alternation Task
Journal of Cognitive Neuroscience
A Computational Model of How the Basal Ganglia Produce Sequences
Journal of Cognitive Neuroscience
A tutorial on particle filters for online nonlinear/non-GaussianBayesian tracking
IEEE Transactions on Signal Processing
AIME '07 Proceedings of the 11th conference on Artificial Intelligence in Medicine
A Similarity and Fuzzy Logic-Based Approach to Cerebral Categorisation
Proceedings of the 2006 conference on ECAI 2006: 17th European Conference on Artificial Intelligence August 29 -- September 1, 2006, Riva del Garda, Italy
SimBa: a fuzzy similarity-based modelling framework for large-scale cerebral networks
ICANN'07 Proceedings of the 17th international conference on Artificial neural networks
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The understanding and the prediction of the clinical outcomes of focal or degenerative cerebral lesions, as well as the assessment of rehabilitation procedures, necessitate knowing the cerebral substratum of cognitive or sensorimotor functions. This is achieved by activation studies, where subjects are asked to perform a specific task while data of their brain functioning are obtained through functional neuroimaging techniques. Such studies, as well as animal experiments, have shown that sensorimotor or cognitive functions are the offspring of the activity of large-scale networks of anatomically connected cerebral regions. However, no one-to-one correspondence between activated networks and functions can be found. Our research aims at understanding how the activation of large-scale networks derives from cerebral information processing mechanisms, which can only explain apparently conflicting activation data. Our work falls at the crossroads of neuroimaging interpretation techniques and computational neuroscience. Since knowledge in cognitive neuroscience is permanently evolving, our research aims more precisely at defining a new modeling formalism and at building a flexible simulator, allowing a quick implementation of the models, for a better interpretation of cerebral functional images. It also aims at providing plausible models, at the level of large-scale networks, of cerebral information processing mechanisms in humans. In this paper, we propose a formalism, based on dynamic Bayesian networks (DBNs), that respects the following constraints: an oriented, networked architecture, whose nodes (the cerebral structures) can all be different, the implementation of causality-the activation of a structure is caused by upstream nodes' activation-the explicit representation of different time scales (from 1ms for the cerebral activity to many seconds for a PET scan image acquisition), the representation of cerebral information at the integrated level of neuronal populations, the imprecision of functional neuroimaging data, the nonlinearity and the uncertainty in cerebral mechanisms, and brain's plasticity (learning, reorganization, modulation). One of the main problems, nonlinearity, has been tackled thanks to new extensions of the Kalman filter. The capabilities of the formalism's current version are illustrated by the modeling of a phoneme categorization process, explaining the different cerebral activations in normal and dyslexic subjects.