Graph-theoretic formalization of hybridization in DNA sticker complexes

  • Authors:

  • Robert Brijder;Joris J. Gillis;Jan Bussche

  • Affiliations:

  • Hasselt University and transnational University of Limburg, Diepenbeek, Belgium;Hasselt University and transnational University of Limburg, Diepenbeek, Belgium;Hasselt University and transnational University of Limburg, Diepenbeek, Belgium

  • Venue:
  • Natural Computing: an international journal
  • Year:
  • 2013

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Abstract

Sticker complexes are a formal graph-based data model for a restricted class of DNA complexes, motivated by potential applications to databases. This data model allows for a purely declarative definition of hybridization. We introduce the notion of terminating hybridization, which intuitively means that only a finite number of different products can be generated. We characterize this notion in purely graph-theoretic terms. Under a finite alphabet, each product is shown to be of polynomial size. Yet, terminating hybridization can still produce results of exponential size, in that there may be exponentially many different (nonisomorphic) finished products. We indicate a class of complexes where hybridization is guaranteed to be polynomially bounded.