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This article describes work at NASA's Johnson Space Center on developinghuman-centered, intelligent control software. The purpose of these intelligent systems isto control crew life support systems in a manner that operates autonomously much of thetime, yet supports human interaction and intervention when needed. The authors describetwo control systems developed and fielded at JSC: an air regeneration system used during a90-day manned test and a water recovery system used during more than a year ofground-based operations. They discuss the lessons learned in human-centered computing whendeveloping and deploying this control software. They also describe recent work on anarchitecture for distributed human interaction with semiautonomous control software thatwas derived from their experience with these systems.