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This article presents a human-centered work system design method based on modeling and simulating work practice-that is, what people actually do. Rather than abstracting human behavior as work processes or tasks-functional idealizations of the work to be accomplished-the authors model people's activities comprehensively and chronologically throughout the day. An analysis of how work gets done must be open to understanding the effects of behaviors in different places and times, details often omitted in a product-oriented task analysis. This method is human centered because it focuses on how people organize their work life and the details of their practices. This approach best suggests work system transformations, including any different tools and processes that might eventually be required.