Recognizing DNA graphs is difficult

  • Authors:
  • Rudi Pendavingh;Petra Schuurman;Gerhard J. Woeginger

  • Affiliations:
  • Department of Mathematics and Computing Science, Eindhoven University of Technology, P.O. Box 513, NL-5600 MB Eindhoven, Netherlands;Department of Mathematics and Computing Science, Eindhoven University of Technology, P.O. Box 513, NL-5600 MB Eindhoven, Netherlands;Department of Mathematics, University of Twente, P.O. Box 217, 7500 AE Enschede, Netherlands and Institut für Mathematik, Technische Universität Graz, Steyrergasse 30, A-8010 Graz, Austr ...

  • Venue:
  • Discrete Applied Mathematics - Special issue: Computational molecular biology series issue IV
  • Year:
  • 2003

Quantified Score

Hi-index 0.00

Visualization

Abstract

DNA graphs are the vertex induced subgraphs of De Bruijn graphs over a four letter alphabet. In this paper, we prove the NP-hardness of various recognition problems for subgraphs of De Bruijn graphs; in particular, the recognition of DNA graphs is shown to be NP-hard. As a consequence, two open questions from a recent paper by Biazewicz et al. (Discrete Appl. Math. 98, (1999) 1) are answered in the negative.