Rapid dynamic programming algorithms for RNA secondary structure

  • Authors:
  • Michael S Waterman;Temple F Smith

  • Affiliations:
  • Departments of Mathematics and of Biological Sciences, University of Southern California, Los Angeles, California 90089-1113 U.S.A.;Department of Biostatistics, Harvard University, 44 Binney Street, Boston, Massachusetts 02115 U.S.A.

  • Venue:
  • Advances in Applied Mathematics
  • Year:
  • 1986

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Abstract

Prediction of RNA secondary structure from the linear RNA sequence is an important mathematical problem in molecular biology. Dynamic programming methods are currently the most useful computer technique but are frequently very expensive in running time. In this paper new dynamic programming algorithms are presented which reduce the required computation. The first polynomial time algorithm is given for predicting general secondary structure.