Unsupervised learning of Bayesian networks via estimation of distribution algorithms: an application to gene expression data clustering

  • Authors:
  • J. M. Peña;J. A. Lozano;P. Larrañaga

  • Affiliations:
  • Department of Computer Science, Aalborg University, Fredrik Bajers Vej 7E, DK-9220 Aalborg, Denmark;Department of Computer Science and Artificial Intelligence, University of the Basque Country, Paseo Manuel de Lardizábal 1, E-20018 Donostia-San Sebastián, Spain;Department of Computer Science and Artificial Intelligence, University of the Basque Country, Paseo Manuel de Lardizábal 1, E-20018 Donostia-San Sebastián, Spain

  • Venue:
  • International Journal of Uncertainty, Fuzziness and Knowledge-Based Systems - New trends in probabilistic graphical models
  • Year:
  • 2004

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Abstract

This paper proposes using estimation of distribution algorithms for unsupervised learning of Bayesian networks, directly as well as within the framework of the Bayesian structural EM algorithm. Both approaches are empirically evaluated in synthetic and real data. Specifically, the evaluation in real data consists in the application of this paper's proposals to gene expression data clustering, i.e., the identification of clusters of genes with similar expression profiles across samples, for the leukemia database. The validation of the clusters of genes that are identified suggests that these may be biologically meaningful.