Inferring domain-domain interactions from protein-protein interactions
Proceedings of the sixth annual international conference on Computational biology
Opportunities for actuated tangible interfaces to improve protein study
CHI '09 Extended Abstracts on Human Factors in Computing Systems
International Journal of Data Mining and Bioinformatics
Advances in Artificial Intelligence - Special issue on artificial intelligence in neuroscience and systems biology: lessons learnt, open problems, and the road ahead
Predicting functional protein-protein interactions based on computational methods
LSMS'07 Proceedings of the 2007 international conference on Life System Modeling and Simulation
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Discovery of the protein interactions that take place within a cell can provide a starting point for understanding biological regulatory pathways. Global interaction patterns among proteins, for example, can suggest new drug targets and aid the design of new drugs by providing a clearer picture of the biological pathways in the neighborhoods of the drug targets. High-throughput experimental screens have been developed to detect protein---protein interactions, however, they show high rates of errors in terms of false positives and false negatives. Many computational approaches have been proposed to tackle the problem of protein---protein interaction prediction. They range from comparative genomics based methods to data integration based approaches. Challenging properties of protein---protein interaction data have to be addressed appropriately before a higher quality interaction map with better coverage can be achieved. This paper presents a survey of major works in computational prediction of protein---protein interactions, explaining their assumptions, main ideas, and limitations.