Combinatorial optimization: algorithms and complexity
Combinatorial optimization: algorithms and complexity
IEEE Transactions on Computers
Bipartite graphs and their applications
Bipartite graphs and their applications
Design of Fault-Tolerant and Dynamically-Reconfigurable Microfluidic Biochips
Proceedings of the conference on Design, Automation and Test in Europe - Volume 2
Concurrent Testing of Droplet-Based Microfluidic Systems for Multiplexed Biomedical Assays
ITC '04 Proceedings of the International Test Conference on International Test Conference
Droplet routing in the synthesis of digital microfluidic biochips
Proceedings of the conference on Design, automation and test in Europe: Proceedings
Multiple fault diagnosis in digital microfluidic biochips
ACM Journal on Emerging Technologies in Computing Systems (JETC)
Computer-Aided Design and Test for Digital Microfluidics
IEEE Design & Test
Engineering of Software-Intensive Systems: State of the Art and Research Challenges
Software-Intensive Systems and New Computing Paradigms
Efficient parallel testing and diagnosis of digital microfluidic biochips
ACM Journal on Emerging Technologies in Computing Systems (JETC)
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Microfluidics-based biochips for biochemical analysis are currently receiving much attention. They automate highly repetitive laboratory procedures by replacing cumbersome equipment with miniaturized and integrated systems. As these microfluidics-based microsystems become more complex, manufacturing yield will have significant influence on production volume and product cost. We propose an interstitial redundancy approach to enhance the yield of biochips that are based on droplet-based digital microfluidics. In this design method, spare cells are placed in the interstitial sites within the microfluidic array, and they replace neighboring faulty cells via local reconfiguration. The proposed design method is evaluated using a set of concurrent real-life bioassays. The defect-tolerant design approach based on space redundancy and local reconfiguration is expected to facilitate yield enhancement of microfluidics-based biochips, especially for the emerging marketplace.