Ontology-Centered Syndromic Surveillance for Bioterrorism
IEEE Intelligent Systems
An Ontology-Driven Mediator for Querying Time-Oriented Biomedical Data
CBMS '06 Proceedings of the 19th IEEE Symposium on Computer-Based Medical Systems
Decision support tools for clinical trial design
Artificial Intelligence in Medicine
Proceedings of the 2008 conference on Formal Ontology in Information Systems: Proceedings of the Fifth International Conference (FOIS 2008)
Design patterns for clinical guidelines
Artificial Intelligence in Medicine
Using semantic web technologies for clinical trial recruitment
ISWC'10 Proceedings of the 9th international semantic web conference on The semantic web - Volume Part II
OnWARD: Ontology-driven web-based framework for multi-center clinical studies
Journal of Biomedical Informatics
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The increasing complexity of clinical trials has generated an enormous requirement for knowledge and information specification at all stages of the trials, including planning, documentation, implementation, and analysis. We are building a knowledge-based framework (Epoch) to support the management of clinical trials. We are tailoring this approach to the Immune Tolerance Network (ITN), an international research consortium developing new therapeutics in immune-mediated disorders. In the broad spectrum of trial management activities, we currently target two areas that are vital to the successful implementation of a trial: (1) tracking study participants as they advance through the trials, and (2) tracking biological specimens as they are processed at the trial laboratories. The core of our software architecture is a suite of ontologies that conceptualizes relevant clinical trial domain. Our approach can provide ITN and other research organizations a stable and consistent knowledge source for clinical-trial software applications.