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This paper details a usability study on a bioinformatics visualization tool. The tool was redesigned based on a usability engineering framework called UX-P (User Experiences to Patterns) that leverages personas and patterns as primary design directives, and encourages on-going usability testing throughout the design lifecycle. The goals were to carry out a design project using the UX-P framework, to assess the usability of the resulting prototype, and to mitigate the test results into useful recommendations.