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The paper explores regional gender differences in information systems adoption based on a sample of 496 Chinese individuals from four universities and one firm, by a lens of theory of planned behavior. It enriches the literature by explaining and examining the moderating effects of gender on the relationships between antecedents and behavioral intention of using information systems for Chinese users. Contrary to prior findings in the US-based research, Chinese women were found to be more strongly influenced by their computer attitudes whereas Chinese men were found to be more strongly affected by their subject norms. Perceived behavior control was important for both sexes without significant difference. The results were robust across prior experience, ages, educational levels, as well as academic disciplines and job occupations. Meanwhile, the paper uncovers under what conditions perceived behavior control and subject norms will be salient determinants of Chinese user acceptance of information systems. Practical implications about gender sensitivity in information systems adoption are discussed.