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Even though the benefits of usability have widely been proven, it seems that development-oriented companies face many difficulties to introduce usability practices into their defined development processes. This paper describes the overall methodology deployed as an attempt to achieve a closer integration of usability practices in the software development process. Model-Driven Engineering (MDE) is used as a basis for this integration. Providing a precise framework composed of models and transformations, it allows to track usability problems and to highlight where exactly they occur in the development process. We will thus be able to link every step of the process to specific ergonomic inputs and to study their consequences on the usability of the generated system. Because MDE will only be used as a way among others to investigate some hypotheses on usability and User-Centered Design (UCD) in general, our results are expected to provide valuable and generic information on usability and UCD processes.