Design of robust metabolic pathways

Authors:
Renato Umeton;Giovanni Stracquadanio;Anilkumar Sorathiya;Pietro Liò;Alessio Papini;Giuseppe Nicosia
Affiliations:
MIT Cambridge, MA;Johns Hopkins University, Baltimore, MD;U. of Cambridge, Cambridge, UK;U. of Cambridge, Cambridge, UK;U. of Florence, Firenze, Italy;U. of Catania, Catania, Italy
Venue:
Proceedings of the 48th Design Automation Conference
Year:
2011

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Abstract

In this paper we investigate plant photosynthesis and microbial fuel cells. We report the following: 1) we introduce and validate a novel multi-objective optimization algorithm, PMO2; 2) in photosynthesis we increase the yield of 135%, while in Geobacter sulfurreducens we determine the tradeoff for growth versus redox properties; 3) finally, we discuss Pareto-Front as an estimator of robust metabolic pathways.