Successive State Transitions with I/O Interface by Molecules
DNA '00 Revised Papers from the 6th International Workshop on DNA-Based Computers: DNA Computing
DNA 7 Revised Papers from the 7th International Workshop on DNA-Based Computers: DNA Computing
Aqueous Solutions of Algorithmic Problems: Emphasizing Knights on a 3 x 3
DNA 7 Revised Papers from the 7th International Workshop on DNA-Based Computers: DNA Computing
Molecular computing paradigm – toward freedom from Turing's charm
Natural Computing: an international journal
Cascading Whiplash PCR with a Nicking Enzyme
DNA8 Revised Papers from the 8th International Workshop on DNA Based Computers: DNA Computing
Aqueous computing: a survey with an invitation to participate
Journal of Computer Science and Technology
DNA13'07 Proceedings of the 13th international conference on DNA computing
Aqueous computing with DNA hairpin-based RAM
DNA'04 Proceedings of the 10th international conference on DNA computing
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Head proposed a framework of aqueous computing as a code design free molecular computing. Aqueous computing handles an aqueous solution of general-purpose memory molecules with a small set of elementary laboratory operations. It fits to solve a certain pattern of NP complete problems. We focus upon scaling the address space up and propose another biomolecular realization. Peptide nucleic acid (PNA) is an artificial analogue of DNA. Since PNA-DNA hybrid has higher melting temperature than DNA-DNA case, PNA will take over hydrogen bonds and displace itself into a double strand DNA. This phenomenon can be regarded as an irreversible write-once operation on a memory molecule. PNA brings a much larger address space than natural enzymes can provide. In this paper, we propose elementary operations for aqueous computing with PNA and realize one bit memory for a feasibility study to confirm strand displacement by PNA. We also propose an idea to copy a memory state upon a DNA sequence by using whiplash PCR.