Biomolecular swarms—an agent-based model of the lactose operon

  • Authors:
  • Christian Jacob;Ian Burleigh

  • Affiliations:
  • Aff1 Aff2;Department of Computer Science, Faculty of Science, University of Calgary, Alberta, Canada

  • Venue:
  • Natural Computing: an international journal
  • Year:
  • 2004

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Abstract

We present our latest version of a swarm-based, 3-dimensional model of the lactose (lac) operon gene regulatory system. The lac operon is a well-understood genetic switch capable of self-regulation dependent on the energy source of lactose. Our model includes a 3D visualisation which simulates proteins as agents with physical properties that interact with DNA, molecules, and other proteins, incorporating many of the important aspects of a genetic regulatory system. Our model utilizes a decentralized swarm approach with multiple agents acting independently -- according to local interaction rules -- to exhibit complex emergent behaviours, which constitute the externally observable and measurable switching behaviour.