The design of DNA self-assembled computing circuitry

Authors:
Chris Dwyer;Leandra Vicci;John Poulton;Dorothy Erie;Richard Superfine;Sean Washburn;Russell M. Taylor, II
Affiliations:
Department of Electrical and Computer Engineering, Duke University, Durham, NC;Department of Computer Science, University of North Carolina at Chapel Hill, NC;Rambus, Inc., Los Altos, CA;Department of Chemistry, University of North Carolina at Chapel Hill, NC;Department of Physics and Astronomy, University of North Carolina at Chapel Hill, NC;Department of Physics and Astronomy, University of North Carolina at Chapel Hill, NC;Department of Computer Science, University of North Carolina at Chapel Hill, NC
Venue:
IEEE Transactions on Very Large Scale Integration (VLSI) Systems - Nanoelectronic circuits and systems
Year:
2004

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Abstract

We present a design methodology for a nanoscale selfassembling fabrication process that uses the specificity of DNA hybridization to guide the formation of electrical circuitry. Custom design software allows us to specify the function of a structure in a way similar to that used by VLSI circuit designers. In an analogous manner to generating masks for a photolithographic process, our software generates an assembly procedure including DNA sequence allocation. We have found that the number of unique DNA sequences needed to assemble a structure scales with its surface area. Using a simple face-serial assembly order we can specify an unambiguous assembly sequence for a structure of any size with only 15 unique DNA sequences.