Computational Biology and Chemistry
Protein Structure Prediction with Large Neighborhood Constraint Programming Search
CP '08 Proceedings of the 14th international conference on Principles and Practice of Constraint Programming
BEBI'08 Proceedings of the 1st WSEAS international conference on Biomedical electronics and biomedical informatics
Computers in Biology and Medicine
On Lattice Protein Structure Prediction Revisited
IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB)
Computers in Biology and Medicine
Proceedings of the 2nd ACM Conference on Bioinformatics, Computational Biology and Biomedicine
International Journal of Bioinformatics Research and Applications
ICIC'13 Proceedings of the 9th international conference on Intelligent Computing Theories and Technology
Computational Biology and Chemistry
Computational Biology and Chemistry
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Motivation: Homology models of proteins are of great interest for planning and analysing biological experiments when no experimental three-dimensional structures are available. Building homology models requires specialized programs and up-to-date sequence and structural databases. Integrating all required tools, programs and databases into a single web-based workspace facilitates access to homology modelling from a computer with web connection without the need of downloading and installing large program packages and databases. Results: SWISS-MODEL workspace is a web-based integrated service dedicated to protein structure homology modelling. It assists and guides the user in building protein homology models at different levels of complexity. A personal working environment is provided for each user where several modelling projects can be carried out in parallel. Protein sequence and structure databases necessary for modelling are accessible from the workspace and are updated in regular intervals. Tools for template selection, model building and structure quality evaluation can be invoked from within the workspace. Workflow and usage of the workspace are illustrated by modelling human Cyclin A1 and human Transmembrane Protease 3. Availability: The SWISS-MODEL workspace can be accessed freely at http://swissmodel.expasy.org/workspace/ Contact: Torsten.Schwede@unibas.ch Supplementary information: Supplementary data are available at Bioinformatics online.