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The use of very deep submicron technology makes VLSI-based digital systems more susceptible to transient or soft errors, and thus compromises their reliability. This paper proposes an architecture inspired by the human immune system that allows tolerance of such errors. An error in a digital system designed using the proposed architecture is treated as an antigen by the system. Using its distributed defense mechanism the system heals itself from the effect of the error. A major advantage of this architecture is that, the outputs of functional cells are connected to the inputs of other physically adjacent functional cells without having to go through complicated routing.